Shlok 153

One should leave the place that they reside within, if some natural disaster strikes, poverty or unfavourable times (Duskalasya) strike or if one is harassed (Upadrava) in such place due to a wicked ruler.  Similarly they should leave such place if one looses their honour or reputation (Laaja), wealth (Dhana) or even their life (Prana).  This is the best advice, to save oneself from such tyranny by leaving such place.